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Steve Martin
| - Brother | Richard Gere
| - Choreographer | Lily Tomlin
| - Dr. Selma Dritz | Anjelica Huston
| - Dr. Betsy Reisz | Alan Alda
| - Dr. Robert Gallo | Lawrence Monoson
| - Chip | Michael Kearns
| - Cleve | Christopher John Fields
| - Lawyer | Tom Schanley
| - Waiter | Neal Lerner
| - 1st Man | John Durbin
| - 6th Man | Martin Raymond
| - 4th Man | Miguel Perez
| - Reporter | Ian McKellen
| - Bill Kraus | Saul Rubinek
| - Dr. Curran | Jeffrey Nordling
| - Gaetan Dugas | David Marshall Grant
| - Dennis Seeley | David Clennon
| - Mr. Johnstone | B.D. Wong
| - Kico Govantes | Peter McRobbie
| - Dr. Max Essex | Carey Eidel
| - Tennis Player | Patrick Gorman
| - Charles Dauget | Donal Logue
| - Bobbi Campbell | Phil Collins
| - Eddie Papasano | Swoosie Kurtz
| - Mrs. Johnstone | Valeri Ross
| - Jim's Secretary | Glenne Headly
| - Dr. Mary Guinan | Michael Winters
| - Middle-aged Man | Jack Laufer
| - Brian McDonough | Richard Jenkins
| - Dr. Marc Conant | Matthew Modine
| - Dr. Don Francis | Angela Paton
| - Woman in Denver | Reg E. Cathey
| - Staff Doctor #2 | Sierra Pecheur
| - Female Reporter | Charles Martin Smith
| - Dr. Harold Jaffe | Alex Courtney
| - Dr. Mika Popovic | Stephen Spinella
| - Brandy Alexander | William Wintersole
| - Dr. Paul Florino | Christian Clemenson
| - Dr. Dale Lawrence | Christopher Carroll
| - Dr. Aaron Kellner | Bud Cort
| - Antique Shop Owner | Ken Jenkins
| - Dr. Dennis Donohue | Patrick Bauchau
| - Dr. Luc Montagnier | Nathalie Baye
| - Dr. Francoise Barre | Rob La Belle
| - Gay Rights Activist | Tchéky Karyo
| - Dr. Willy Rozenbaum | Alan Barry
| - Hemophiliac Patient | Rosemarie Murphy
| - Blood Bank Executive | Walter Addison
| - Blood Bank Executive | John del Regno
| - Man in Grand Central | Rene LeVant
| - Blood Bank Executive | David Dukes
| - Dr. Mervyn Silverman | Clyde Kusatsu
| - Blood Bank Executive | Thomas Kopache
| - Blood Bank Executive | Richard Fancy
| - Dr. Michael Gottlieb | Jack Kenny
| - San Francisco Activist | Jill Andre
| - Red Cross Spokesperson | Dakin Matthews
| - Congressman Phil Burton | James Greene
| - Dr. Alvin Freedman-Kien | Richard Masur
| - William W. Darrow, Ph.D | Ronald Guttman
| - Dr. Jean-Claude Chermann | Dave Florek
| - Doughnut Shop Counterman | Laura Innes
| - Hemophiliac Representative | Mogens Eckert
| - Chief Executive (Copenhagen) |
Allan A. Apone
| - Makeup | Carter Burwell
| - Composer (Music Score) | Patti Callicott
| - Costume Designer | Paul Elliott
| - Cinematographer | Lois Freeman-Fox
| - Editor | Victoria Paul
| - Production Designer | Sarah Pillsbury
| - Producer | Midge Sanford
| - Producer | Arnold Schulman
| - Co-producer | Arnold Schulman
| - Screenwriter | Michael Spatola
| - Makeup | Aaron Spelling
| - Executive Producer | Roger Spottiswoode
| - Director | Edward Teets
| - Co-producer | Albert M. Shapiro
| - Associate Producer | Albert M. Shapiro
| - First Assistant Director | Chris Squires
| - Camera Operator | Lee Mayman
| - Art Director | Randy Shilts
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